HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.

@article{Figaro2008HemK2PE,
  title={HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.},
  author={Sabine Figaro and Nathalie Scrima and R. H. Buckingham and Val{\'e}rie Heurgu{\'e}-Hamard},
  journal={FEBS letters},
  year={2008},
  volume={582 16},
  pages={
          2352-6
        }
}
The ubiquitous tripeptide Gly-Gly-Gln in class 1 polypeptide release factors triggers polypeptide release on ribosomes. The Gln residue in both bacterial and yeast release factors is N5-methylated, despite their distinct evolutionary origin. Methylation of eRF1 in yeast is performed by the heterodimeric methyltransferase (MTase) Mtq2p/Trm112p, and requires eRF3 and GTP. Homologues of yeast Mtq2p and Trm112p are found in man, annotated as an N6-DNA-methyltransferase and of unknown function. Here… CONTINUE READING

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