Helplessness as a strategy for avoiding antiglobulin responses to therapeutic monoclonal antibodies.

Abstract

The antiglobulin (anti-Ig) response to therapeutic monoclonal antibodies (mAbs) poses a significant obstacle to their routine application in man. Whilst humanization has lessened the problem, repeated courses of humanized mAbs still sensitise some patients. Previous work suggested that unresponsiveness to cell-binding (therapeutic) mAbs could not be… (More)

Topics

Cite this paper

@article{Isaacs1994HelplessnessAA, title={Helplessness as a strategy for avoiding antiglobulin responses to therapeutic monoclonal antibodies.}, author={John Dudley Isaacs and H B Waldmann}, journal={Therapeutic immunology}, year={1994}, volume={1 6}, pages={303-12} }