Helping hands, healthy body? Oxytocin receptor gene and prosocial behavior interact to buffer the association between stress and physical health

  title={Helping hands, healthy body? Oxytocin receptor gene and prosocial behavior interact to buffer the association between stress and physical health},
  author={Michael Poulin and Ellen Alison Holman},
  journal={Hormones and Behavior},
Genetic differential susceptibility to the parent-child relationship quality and the life span development of compassion.
Only participants who carry alleles associated with low dopamine signaling activity had higher levels of compassion when growing up with emotionally warm parents, whereas they had lower levels ofcompassion when their parents were emotionally cold.
Oxytocin Pathway Genes (CD38, OXTR) and Psychosocial Characteristics Defined According to Strengths and Difficulties Questionnaire in Urban Siberian Adolescents: A School-based Study
Oxytocin (OT) is regarded as an extremely important prosocial neuropeptide that dramatically affects the establishment of social connections from infancy to adulthood. OT effects on the
Only the Lonely: Expression of Proinflammatory Genes Through Family Cancer Caregiving Experiences.
Findings suggest that caregiving-related transcriptional effects appear to be most pronounced when caregivers experience low social support and loneliness, as well as little meaning or purpose in their caregiving.
Common variants of the oxytocin receptor gene do not predict the positive mood benefits of prosocial spending.
There is conclusive evidence that the benefits of generosity were not moderated by individual differences in OXTR single nucleotide polymorphisms, and the importance of publishing null results to build cumulative knowledge linking neurobiological factors to positive emotional experiences is highlighted.
Stress-buffering effects of volunteering on salivary cortisol: Results from a daily diary study.
The Oxytocin Receptor Gene (OXTR) in Relation to State Levels of Loneliness in Adolescence: Evidence for Micro-Level Gene-Environment Interactions
A relation was found between the OXTR rs53576 variant and state loneliness, in girls only, and adolescents with an A allele were more affected by negative perceptions of company than GG carriers, on weekend days only.
ff ects of volunteering on salivary cortisol : Results from a daily diary study
Based on the theoretical foundations of the caregiving system model, which holds that prosocial behavior can be conceptualized in relation to a neurobiological stress-buffering mechanism, we


Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans
Results indicate that genetic variation of the oxytocin system modulates the effectiveness of positive social interaction as a protective buffer against a stressful experience.
Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans
The results provide evidence of how a naturally occurring genetic variation of the oxytocin receptor relates to both empathy and stress profiles and suggest that AA/AG individuals displayed higher physiological and dispositional stress reactivity than GG individuals.
Oxytocin and social affiliation in humans
  • R. Feldman
  • Psychology, Biology
    Hormones and Behavior
  • 2012
Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking
The findings suggest that OXTR rs53576 is sensitive to input from the social environment, specifically cultural norms regarding emotional social support seeking and indicates that psychological distress and culture are important moderators that shape behavioral outcomes associated with OX TR genotypes.
The Neurogenetics of Nice
Oxytocin, vasopressin, and their receptor genes influence prosocial behavior in the laboratory and in the context of close relationships. These peptides may also promote social engagement following
A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function
Evidence for structural alterations in key oxytocinergic regions emerged, particularly in the hypothalamus, and these neural characteristics predicted lower levels of reward dependence in male risk allele carriers.
Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting.
This first study on the role of both OXTR and 5-HTT genes in human parenting points to molecular genetic differences that may be implicated in the production of oxytocin explaining differences in sensitive parenting.
The Social Dimension of Stress Reactivity
It is shown that stress triggers social approach behavior, which operates as a potent stress-buffering strategy in humans, thereby providing evidence for the tend-and-befriend hypothesis.
Human Affection Exchange: XIII. Affectionate Communication Accelerates Neuroendocrine Stress Recovery
Results indicated that, compared to the control groups, those in the experimental group experienced accelerated cortisol recovery following exposure to the acute stressors.