Helper virus-free transfer of human immunodeficiency virus type 1 vectors.

@article{Richardson1995HelperVT,
  title={Helper virus-free transfer of human immunodeficiency virus type 1 vectors.},
  author={Jason R. Richardson and J F Kaye and L. A. Child and Andrew Michael Lindsay Lever},
  journal={The Journal of general virology},
  year={1995},
  volume={76 ( Pt 3)},
  pages={691-6}
}
Recombinant vectors based on the type 1 human immunodeficiency virus (HIV-1) can be used to deliver genes into cells expressing the HIV receptor, CD4. We have used a transient RNA packaging system to compare the safety and efficacy of HIV-1 vector transduction by wild-type and replication-deficient helper viruses. Helper virus-free vector transfer was consistently achieved when the helper virus gag-pol and env genes were expressed from separate plasmids such that two recombination events were… CONTINUE READING

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