Corpus ID: 24724082

Helper cell function of Leukemic Leu-2a+, histamine receptor+, T gamma lymphocytes.

@article{Siegal1982HelperCF,
  title={Helper cell function of Leukemic Leu-2a+, histamine receptor+, T gamma lymphocytes.},
  author={Frederick P. Siegal and Pietro Rambotti and Marta Siegal and Carlos Alberto Parra L{\'o}pez and M Smith and Terry F Davies and Michael E. Osband and Solomon Estren},
  journal={Journal of immunology},
  year={1982},
  volume={129 4},
  pages={
          1775-81
        }
}
Leukemic cells from a patient with an 11-yr history of chronic lymphocytic leukemia (CLL) were found to have the surface phenotype Leu-1+, Leu-2a+, Leu-3a-, sheep erythrocyte rosette+, IgGFc receptor+. The cells also bore a receptor for histamine inhibitable by cimetidine (H-2). The clonal nature of the proliferation was documented by the presence of a consistent marker chromosome (22-trisomy) in metaphases elicited by culture with T cell growth factors. Although the surface phenotype suggested… Expand
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