Helper T cells regulate type-2 innate immunity in vivo

@article{Shinkai2002HelperTC,
  title={Helper T cells regulate type-2 innate immunity in vivo},
  author={Kanade Shinkai and Markus Mohrs and Richard M Locksley},
  journal={Nature},
  year={2002},
  volume={420},
  pages={825-829}
}
Type-2 immunity requires orchestration of innate and adaptive immune responses to protect mucosal sites from pathogens. Dysregulated type-2 responses result in allergy or asthma. T helper 2 (TH2) cells elaborate cytokines, such as interleukin (IL)-4, IL-5, IL-9 and IL-13, which work with toxic mediators of innate immune cells to establish environments that are inhospitable to helminth or arthropod invaders. The importance of TH2 cells in coordinating innate immune cells at sites of inflammation… CONTINUE READING

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