Helper T cell anergy: from biochemistry to cancer pathophysiology and therapeutics

@article{Appleman2001HelperTC,
  title={Helper T cell anergy: from biochemistry to cancer pathophysiology and therapeutics},
  author={Leonard Joseph Appleman and Dimitrios Tzachanis and Thomas Grader-Beck and Andre A.F.L. van Puijenbroek and Vassiliki A Boussiotis},
  journal={Journal of Molecular Medicine},
  year={2001},
  volume={78},
  pages={673-683}
}
Tolerance in vivo and its in vitro counterpart, anergy, are defined as the state in which helper T lymphocytes are alive but incapable of producing IL-2 and expanding in response to optimal antigenic stimulation. Anergy is induced when the T cell receptor (TCR) is engaged by antigen in the absence of costimulation or IL-2. This leads to unique intracellular signaling events that stand in contrast to those triggered by coligation of the TCR and costimulatory receptors. Specifically, anergy is… CONTINUE READING