Helospectin and pituitary adenylate cyclase activating polypeptide in the human vagina

@article{Graf1995HelospectinAP,
  title={Helospectin and pituitary adenylate cyclase activating polypeptide in the human vagina},
  author={Anton H. Graf and A Schiechl and Gerhard W. Hacker and Cornelia Hauser-kronberger and Horst Steiner and Akira Arimura and Frank Sundler and Alfons Staudach and Otto Dietze},
  journal={Regulatory Peptides},
  year={1995},
  volume={55},
  pages={277-286}
}

Pituitary adenylate cyclase activating polypeptide (PACAP) is localized in human dermal neurons and causes histamine release from skin mast cells

Pituitary adenylate cyclase activating polypeptide is found in human skin and is capable of releasing histamine from skin mast cells and was found to be twice as efficient as PACAP-27, whereas calcitonin gene-related peptide did not release histamine.

Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions.

The current knowledge concerning the multiple actions of PACAP in the central nervous system and in various peripheral organs including the endocrine glands, the airways, and the cardiovascular and immune systems are reviewed, as well as the different effects ofPACAP on a number of tumor cell types.

Pituitary Adenylate Cyclase-Activating Polypeptide

The bronchodilatator and vasorelaxant effects of PACAP, as well as the antiproliferative and neuroprotective actions of the peptide, make it a valuable target for new drug development.

THE ORIGIN AND FUNCTION OF THE PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP)/GLUCAGON SUPERFAMILY

The pituitary adenylate cyclase-activating polypeptide (PACAP) regulates metabolism and the cardiovascular, endocrine, and immune systems, although the physiological event(s) that coordinates PACAP responses remains to be identified.

PACAP in the Urogenital Tract

Although there is still a long way to go before the role of PACAP in the urogenital tract is clarified a number of studies have clearly demonstrated that PACAP could be a sensory and efferent neurotransmitter as well as having autocrine/paracrine functions.

References

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PACAP, a VIP-like peptide, in neurons of the esophagus

Peptide-containing nerve fibers in human airways: distribution and coexistence pattern.

The occurrence, distribution and coexistence pattern of an array of neuropeptides and tyrosine hydroxylase in the human larynx, trachea, bronchi and lungs were studied by immunocytochemistry. A rich

The regional distribution of NPY-, PHM-, and VIP-containing nerves in the human female genital tract.

There is evidence that VIP is a neurotransmitter in the female genital tract, and these results suggest a similar role for NPY and PHM, which are found in the fallopian tube, mainly around the circular muscle coat.