Helodermin-like peptides in thyroid C cells: stimulation of thyroid hormone secretion and suppression of calcium incorporation into bone.

@article{Grunditz1989HeloderminlikePI,
  title={Helodermin-like peptides in thyroid C cells: stimulation of thyroid hormone secretion and suppression of calcium incorporation into bone.},
  author={T. Grunditz and P. Persson and R. H{\aa}kanson and A. Absood and G. B{\"o}ttcher and C. Rerup and F. Sundler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 4},
  pages={
          1357-61
        }
}
  • T. Grunditz, P. Persson, +4 authors F. Sundler
  • Published 1989
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Helodermin is a vasoactive intestinal peptide-like peptide in the salivary gland venom of the lizard Heloderma suspectum. Helodermin-like immunofluorescence was observed in the parafollicular (C) cells in several mammals and in the C cell homologues of the chicken ultimobranchial gland. Thus, helodermin-like peptides coexist with calcitonin. The results of radioimmunoassay agreed with the immunocytochemical findings. HPLC of rat thyroid extracts revealed one major peak of helodermin-like… Expand
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