Helminth-conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo.

@article{Connor2014HelminthconditionedDC,
  title={Helminth-conditioned dendritic cells prime CD4+ T cells to IL-4 production in vivo.},
  author={Lisa M. Connor and Shiau-Choot Tang and Mali Camberis and Graham Le Gros and Franca Ronchese},
  journal={Journal of immunology},
  year={2014},
  volume={193 6},
  pages={
          2709-17
        }
}
Dendritic cells (DC) are critical for the initiation of immune responses; however, their role in priming IL-4-producing Th2 cells in vivo is not fully understood. We used a model of intradermal injection with fluorescent-labeled, nonviable larvae from the helminth parasite nonviable Nippostrongylus brasiliensis L3 larvae (Nb), a strong inducer of Th2 responses, together with IL-4-GFP reporter mice that enable a sensitive detection of IL-4 production to examine the contribution of DC to the… CONTINUE READING
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