Helminth/Parasite Treatment of Multiple Sclerosis

@article{Correale2014HelminthParasiteTO,
  title={Helminth/Parasite Treatment of Multiple Sclerosis},
  author={Jorge Correale},
  journal={Current Treatment Options in Neurology},
  year={2014},
  volume={16},
  pages={1-12},
  url={https://api.semanticscholar.org/CorpusID:26003679}
}
It is strongly recommended that live helminth or ova parasites be administered only to individuals participating in strictly monitored, controlled clinical trials, and much remains to be explored before the field can move from experimental animal models to application in clinical practice.
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24 Citations
Background Citations
11
Methods Citations
1

24 Citations

Intestinal Parasites and Immunomodulation in Neuroinflammatory Disease

The animal studies, the rationale for and the safety and efficacy results of clinical trials of helminth therapy in MS are reviewed, which may provide information that could lead to advances in the understanding of MS pathogenesis.

Helminth therapy – local and systemic activity, on example of inflammatory bowel diseases and multiple sclerosis

Helminth therapy of autoimmunological disorder on multiple sclerosis and inflammatory bowel diseases examples as well as using parasitic compounds as a potential pharmaceutical component are summarized and discussed.

Helminth Therapy: Advances in the use of Parasitic Worms Against Inflammatory Bowel Diseases and its Challenges

Summary Development of modern medicine and better living conditions in the 20th century helped in reducing a number of cases of infectious diseases. During the same time, expansion of…

The role of gut microbiota and diet in experimental autoimmune encephalitis and multiple sclerosis

The current advances in this field are introduced, including the data on Pediococcus acidilactici and Candida kefyr in EAE, and the potential of probiotics in terms of prophylactic or therapeutic treatment options for multiple sclerosis is discussed.

Role of intestinal microbiota in the development of multiple sclerosis.

Role of intestinal microbiota in the development of multiple sclerosis

Parasitic Worms for the Treatment of Neurodegeneration

The article discusses the current status and prospects of clinical use of immunomodulatory parasitic worms in the treatment of autoimmune and inflammatory diseases, including MS and AD.

Ameliorating effects of some trematode antigens on arthritis induced in Wistar rats

Treatment with Sm orFh antigens resulted in significant amelioration in the symptoms of the disease, including paw thickness and deformity measured by X-ray, suggesting that Trematode antigens can be used as a potential therapeutic approach to amelIORate arthritis.

Rapidly progressive respiratory failure after helminth larvae ingestion

This case of rapidly progressive respiratory failure in a patient with systemic sclerosis and pulmonary arterial hypertension as a result of self-administration of parasitic organisms is presented, highlighting the risk of experimental helminth therapy in patients, especially those with underlying respiratory disease.

Gut flora in multiple sclerosis: implications for pathogenesis and treatment

The gut-brain axis refers to complex communications between the gut flora and the immune, nervous, and endocrine systems, which bridges the functions of the gut and the brain.

72 References

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Immune monitoring of Trichuris suis egg therapy in multiple sclerosis patients.

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Immunomodulatory effects of helminths and protozoa in multiple sclerosis and experimental autoimmune encephalomyelitis

This review will focus on recent advances in the field of parasites as beneficial immunomodulators, in multiple sclerosis and the animal model experimental autoimmune encephalomyelitis.

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TSO was well tolerated in the first human study of this novel probiotic in RRMS, and favorable trends were observed in exploratory MRI and immunological assessments.

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Experimental autoimmune encephalomyelitis evolution was not modified by multiple infections with Strongyloides venezuelensis

The results suggest that a Th2‐polarized response without concomitant expansion of Foxp3+ regulatory T cells was not able to modify EAE progression, and suggest that this paradigm might be an oversimplification.

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There is much interest in whether helminth-associated immune regulation may ameliorate allergy and autoimmunity, with investigations in both laboratory models and human trials suggesting that parasites may protect against immunopathological syndromes.

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It is demonstrated that in mice with Schistosoma mansoni ova immunization, the severity of EAE is reduced as measured by decreased clinical scores and CNS cellular infiltrates, and indicates that STAT6 plays a critical role in regulating the ameliorating effect of S. mansoni helminth ova treatment on the autoimmune response.

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