Helix unwinding in the effector region of elongation factor EF-Tu-GDP.

@article{Polekhina1996HelixUI,
  title={Helix unwinding in the effector region of elongation factor EF-Tu-GDP.},
  author={Galina Polekhina and S{\o}ren Thirup and Morten Kjeldgaard and Poul Nissen and Corinna Lippmann and Jens Nyborg},
  journal={Structure},
  year={1996},
  volume={4 10},
  pages={
          1141-51
        }
}
BACKGROUND Elongation factor Tu (EF-Tu) in its GTP conformation is a carrier of aminoacylated tRNAs (aa-tRNAs) to the ribosomal A site during protein biosynthesis. The ribosome triggers GTP hydrolysis, resulting in the dissociation of EF-Tu-GDP from the ribosome. The affinity of EF-Tu for other molecules involved in this process, some of which are unknown, is regulated by two regions (Switch I and Switch II) that have different conformations in the GTP and GDP forms. The structure of the GDP… CONTINUE READING
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