Helix signals in proteins.

@article{Presta1988HelixSI,
  title={Helix signals in proteins.},
  author={Leonard G. Presta and George D. Rose},
  journal={Science},
  year={1988},
  volume={240 4859},
  pages={
          1632-41
        }
}
The alpha helix, first proposed by Pauling and co-workers, is a hallmark of protein structure, and much effort has been directed toward understanding which sequences can form helices. The helix hypothesis, introduced here, provides a tentative answer to this question. The hypothesis states that a necessary condition for helix formation is the presence of residues flanking the helix termini whose side chains can form hydrogen bonds with the initial four-helix greater than N-H groups and final… CONTINUE READING
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