Helix-helix packing in a membrane-like environment.

  title={Helix-helix packing in a membrane-like environment.},
  author={Ismael Mingarro and Arne Elofsson and Gunnar von Heijne},
  journal={Journal of molecular biology},
  volume={272 4},
The unique ability of the glycophorin A transmembrane helix to dimerize in SDS has previously been exploited in studies of the sequence specificity of helix-helix packing in a micellar environment. Here, we have made different insertion mutants in the critical helix-helix interface segment, and find that efficient dimerization can be mediated by a wider range of sequence motifs than suggested by the earlier studies. We also show that certain mutants that are unable to dimerize can nevertheless… CONTINUE READING


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