Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans.

@article{Ashenberg2013HelixBL,
  title={Helix bundle loops determine whether histidine kinases autophosphorylate in cis or in trans.},
  author={Orr Ashenberg and Amy E. Keating and Michael T Laub},
  journal={Journal of molecular biology},
  year={2013},
  volume={425 7},
  pages={1198-209}
}
Bacteria frequently use two-component signal transduction pathways to sense and respond to environmental and intracellular stimuli. Upon receipt of a stimulus, a homodimeric sensor histidine kinase autophosphorylates and then transfers its phosphoryl group to a cognate response regulator. The autophosphorylation of histidine kinases has been reported to occur both in cis and in trans, but the molecular determinants dictating which mechanism is employed are unknown. Based on structural… CONTINUE READING

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