Helix-Grafted Pleckstrin Homology Domains Suppress HIV-1 Infection of CD4-Positive Cells.

@article{Tennyson2016HelixGraftedPH,
  title={Helix-Grafted Pleckstrin Homology Domains Suppress HIV-1 Infection of CD4-Positive Cells.},
  author={Rachel L Tennyson and Susanne N Walker and Terumasa Ikeda and Reuben S Harris and Alan J Kennan and Brian R McNaughton},
  journal={Chembiochem : a European journal of chemical biology},
  year={2016},
  volume={17 20},
  pages={
          1945-1950
        }
}
The size, functional group diversity and three-dimensional structure of proteins often allow these biomolecules to bind disease-relevant structures that challenge or evade small-molecule discovery. Additionally, folded proteins are often much more stable in biologically relevant environments compared to their peptide counterparts. We recently showed that helix-grafted display-extensive resurfacing and elongation of an existing solvent-exposed helix in a pleckstrin homology (PH) domain-led to a… CONTINUE READING
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Suppression of HIV-1 entry by ELMO-derived C-terminal fusion proteins and controls: D21 ELMO

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