Helium preconditioning protects mouse liver against ischemia and reperfusion injury through the PI3K/Akt pathway.

@article{Zhang2014HeliumPP,
  title={Helium preconditioning protects mouse liver against ischemia and reperfusion injury through the PI3K/Akt pathway.},
  author={Rongjia Zhang and Ling Zhang and Anatol Manaenko and Zhouheng Ye and Wenwu Liu and Xuejun Sun},
  journal={Journal of hepatology},
  year={2014},
  volume={61 5},
  pages={1048-55}
}
BACKGROUND & AIMS Hepatic ischemia and reperfusion (I/R) injury is a major complication of liver transplantation, hepatic resection and trauma. Helium preconditioning (HPC) exerts protection against ischemic stress. We investigated potential beneficial effects of HPC on I/R-induced liver injury and investigated mechanisms underlying HPC-induced protection. METHODS We employed a model of segmental warm hepatic I/R on BALB/c mice. Serum ALT was measured and livers were analysed by histology, RT… CONTINUE READING
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American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2011
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