Helium-induced early preconditioning and postconditioning are abolished in obese Zucker rats in vivo.

@article{Huhn2009HeliuminducedEP,
  title={Helium-induced early preconditioning and postconditioning are abolished in obese Zucker rats in vivo.},
  author={R Huhn and A Heinen and N. C. Weber and Raphaela Priscilla Kerindongo and Gezina Tanya Mei Ling Oei and M W Hollmann and Wolfgang Schlack and Benedikt Preckel},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={329 2},
  pages={600-7}
}
Preconditioning is abolished in the prediabetic Zucker obese rat. It has been shown that prevention of mitochondrial permeability transition pore (mPTP) opening is involved in preconditioning by the noble gas helium. Here, we investigated: 1) whether helium induces pre- and postconditioning in Zucker rats and 2) whether possible regulators of the mPTP [i.e., mitochondrial respiration or the extracellular signal-regulated kinase (Erk) 1/2, Akt/glycogen synthase kinase (GSK)-3beta signaling… CONTINUE READING