Helium/Oxygen-Driven Albuterol Nebulization in the Treatment of Children With Moderate to Severe Asthma Exacerbations: A Randomized, Controlled Trial

@article{Kim2005HeliumOxygenDrivenAN,
  title={Helium/Oxygen-Driven Albuterol Nebulization in the Treatment of Children With Moderate to Severe Asthma Exacerbations: A Randomized, Controlled Trial},
  author={In K. Kim and Erin Phrampus and Shekhar Venkataraman and Raymond D. Pitetti and Al Saville and Timothy E Corcoran and Edward J Gracely and Nicole Funt and Ann Thompson},
  journal={Pediatrics},
  year={2005},
  volume={116},
  pages={1127 - 1133}
}
Background. Helium and oxygen mixtures (heliox) increase both pulmonary aerosol delivery and gas delivery relative to oxygen. We aimed to compare the effectiveness of a 70%:30% helium/oxygen (heliox)–driven continuous aerosol delivery versus 100% oxygen-driven delivery in the treatment of asthmatic children with moderate to severe exacerbations. Methods. We enrolled 30 children aged 2 to 18 years who presented to an urban, pediatric emergency department (ED) with moderate to severe asthma as… 
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Highly Influential Citations
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Background Citations
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Methods Citations
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101 Citations

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Citation Type

Helium/oxygen-driven albuterol nebulization in the management of children with status asthmaticus: A randomized, placebo-controlled trial*
  • M. Bigham, B. Jacobs, +5 authors D. Wheeler
  • Medicine
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
  • 2010
TLDR
Despite the previously demonstrated effects of heliox on improved aerosol particle delivery into the distal airways, heliox-powered nebulized albuterol therapy for children admitted to the hospital with moderate to severe status asthmaticus does not shorten hospital length of stay or hasten rates of clinical improvement.
Helium-oxygen therapy for infants with bronchiolitis: a randomized controlled trial.
TLDR
Nebulized racemic epinephrine delivered by helium-oxygen followed by helium -oxygen inhalation therapy delivered by HFNC was associated with a greater degree of clinical improvement compared with that delivered by oxygen among infants with bronchiolitis.
Use of helium-oxygen mixture (Heliox®) in the treatment of obstructive lower airway disease in a pediatric emergency department.
TLDR
Compared to usual aerosol delivery technique, Heliox®-driven salbutamol nebulization is associated with shorter stay in the observation room after 6 h of treatment, and is effective in the treatment of pediatric obstructive disease that responds to bronchodilator therapy.
Heliox-driven β2-agonists nebulization for children and adults with acute asthma: a systematic review with meta-analysis.
  • G. Rodrigo, J. Castro‐Rodriguez
  • Medicine
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2014
In vitro comparison of heliox and oxygen in aerosol delivery using pediatric high flow nasal cannula
TLDR
Using a pediatric model of HFNC, reducing delivered flow from 6 to 3 L/min increased inhaled albuterol delivery ≥2‐fold but eliminated the increase in inhaled drug efficiency associated with heliox.
Use of helium-oxygen mixtures in the treatment of croup: a systematic review
TLDR
There is no evidence to support the use of helium-oxygen therapy in children with croup, and methodologically well-designed and adequately powered randomised controlled trials are needed to determine whether helium- oxygengen inhalation as part of the initial treatment in croup alters outcome.
Use of heliox in children.
TLDR
The rationale and methods for heliox treatment of children with asthma, airway obstruction, bronchiolitis, and croup are reviewed.
Heliox for nonintubated acute asthma patients.
TLDR
Heliox treatment does not have a role to play in the initial treatment of patients with acute asthma, and new evidence suggests certain beneficial effects in patients with more severe obstruction.
Heliox Treatment: Effective for Children with Asthma?
Heliox (helium/oxygen mixture) might be superior to oxygen as a driving gas for aerosol delivery of β-agonists in patients with acute asthma because its lower gas density results in decreased flow…
Heliox-driven albuterol nebulization for asthma exacerbations: an overview.
TLDR
This review begins with heliox inhalation therapy and then addresses heliox as a driving gas for nebulization, including optimal gas mixtures, flow-rate adjustment factors, and nebulizer setup.
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