Heliox improves oxygen delivery and utilization during dynamic exercise in patients with chronic obstructive pulmonary disease.

@article{Chiappa2009HelioxIO,
  title={Heliox improves oxygen delivery and utilization during dynamic exercise in patients with chronic obstructive pulmonary disease.},
  author={Gaspar Rog{\'e}rio da Silva Chiappa and Fernando Queiroga and Ethiane D. S. Meda and Leonardo F Ferreira and Fernando Diefenthaeler and Marcos Andr{\'e} Lima Nunes and Marco Aur{\'e}lio Vaz and Maria Christina Lombardi Oliveira Machado and Luis Eduardo Maia Nery and Jos{\'e} Alberto Neder},
  journal={American journal of respiratory and critical care medicine},
  year={2009},
  volume={179 11},
  pages={1004-10}
}
RATIONALE Normoxic heliox (mixture of 79% He and 21% O(2)) may enhance exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). It remains to be determined whether part of these beneficial effects could be ascribed to increased O(2) delivery (O(2)DEL) to locomotor muscles. OBJECTIVES To investigate the effects of heliox on peripheral O(2)DEL and utilization during exercise in moderate to severe COPD. METHODS Twelve mildly hypoxic or nonhypoxemic men (FEV(1) = 45.0… CONTINUE READING

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