Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells.

@article{Baine2013HeliosIE,
  title={Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells.},
  author={Ian Baine and Samik Basu and Rachel Y Ames and Rani Suzanne Sellers and Fernando Macian},
  journal={Journal of immunology},
  year={2013},
  volume={190 3},
  pages={1008-16}
}
Regulatory T cells (Tregs) play a critical role in maintaining immune tolerance and preventing autoimmune disease. Tregs express the transcription factor Foxp3, which acts as a master regulator of their differentiation and controls their capacity to suppress T cell responses. Tregs have an intrinsically anergic phenotype and do not produce IL-2 or proliferate upon stimulation ex vivo. Recent studies identified that Helios, a member of the Ikaros family of transcription factors, is expressed in… CONTINUE READING