Helicobacter pylori virulence and genetic geography.

@article{Covacci1999HelicobacterPV,
  title={Helicobacter pylori virulence and genetic geography.},
  author={A. Covacci and J. Telford and G. Del Giudice and J. Parsonnet and R. Rappuoli},
  journal={Science},
  year={1999},
  volume={284 5418},
  pages={
          1328-33
        }
}
  • A. Covacci, J. Telford, +2 authors R. Rappuoli
  • Published 1999
  • Medicine, Biology
  • Science
  • Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori. 

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    Pharmacotherapy of Helicobacter pylori-associated gastritis
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 83 REFERENCES
    Bacterial Infections of Humans: Epidemiology and Control
    46
    The Fates of Human Societies (Norton
    • 1997