Helicobacter pylori virulence and genetic geography.

@article{Covacci1999HelicobacterPV,
  title={Helicobacter pylori virulence and genetic geography.},
  author={Antonello Covacci and John L. Telford and Giuseppe Del Giudice and Julie Parsonnet and Rino Rappuoli},
  journal={Science},
  year={1999},
  volume={284 5418},
  pages={1328-33}
}
Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation… CONTINUE READING