Helicobacter pylori virulence and genetic geography.

@article{Covacci1999HelicobacterPV,
  title={Helicobacter pylori virulence and genetic geography.},
  author={A. Covacci and J. Telford and G. del Giudice and J. Parsonnet and R. Rappuoli},
  journal={Science},
  year={1999},
  volume={284 5418},
  pages={
          1328-33
        }
}
Isolated for the first time in 1982 from human gastric biopsy, Helicobacter pylori is responsible for gastritis, peptic ulcer, and gastric cancer. A pathogenicity island acquired by horizontal transfer, coding for a type IV secretion system, is a major determinant of virulence. The infection is now treated with antibiotics, and vaccines are in preparation. The geographic distribution suggests coevolution of man and Helicobacter pylori. 
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