Helicobacter pylori versus the Host: Remodeling of the Bacterial Outer Membrane Is Required for Survival in the Gastric Mucosa

@inproceedings{Cullen2011HelicobacterPV,
  title={Helicobacter pylori versus the Host: Remodeling of the Bacterial Outer Membrane Is Required for Survival in the Gastric Mucosa},
  author={Thomas Wilson Cullen and David K Giles and Lindsey Nan Wolf and Chantal Ecobichon and Ivo Gomperts Boneca and M Stephen Trent},
  booktitle={PLoS pathogens},
  year={2011}
}
Modification of bacterial surface structures, such as the lipid A portion of lipopolysaccharide (LPS), is used by many pathogenic bacteria to help evade the host innate immune response. Helicobacter pylori, a gram-negative bacterium capable of chronic colonization of the human stomach, modifies its lipid A by removal of phosphate groups from the 1- and 4'-positions of the lipid A backbone. In this study, we identify the enzyme responsible for dephosphorylation of the lipid A 4'-phosphate group… CONTINUE READING

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