Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells.

Abstract

OBJECTIVE Helicobacter pylori strains that express the oncoprotein CagA augment risk for gastric cancer. However, the precise mechanisms through which cag(+) strains heighten cancer risk have not been fully delineated and model systems that recapitulate the gastric niche are critical for understanding pathogenesis. Gastroids are three-dimensional organ-like… (More)
DOI: 10.1136/gutjnl-2014-307650

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