Helicobacter pylori mutants defective in RuvC Holliday junction resolvase display reduced macrophage survival and spontaneous clearance from the murine gastric mucosa.

@article{Loughlin2003HelicobacterPM,
  title={Helicobacter pylori mutants defective in RuvC Holliday junction resolvase display reduced macrophage survival and spontaneous clearance from the murine gastric mucosa.},
  author={Michael F Loughlin and Faye M Barnard and David Jenkins and Gary J. Sharples and Peter J. Jenks},
  journal={Infection and immunity},
  year={2003},
  volume={71 4},
  pages={2022-31}
}
Homologous recombination contributes to the extraordinary genetic diversity of Helicobacter pylori and may be critical for surface antigen expression and adaptation to environmental challenges within the stomach. We generated isogenic, nonpolar H. pylori ruvC mutants to investigate the function of RuvC, a Holliday junction endonuclease that resolves recombinant joints into nicked duplex products. Inactivation of ruvC reduced the frequency of homologous recombination of H. pylori between 17- and… CONTINUE READING
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