Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression

@inproceedings{Belair2011HelicobacterPI,
  title={Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression},
  author={C{\'e}dric Belair and Jessica Baud and Sandrine Chabas and Cynthia M. Sharma and J{\"o}rg Vogel and Cathy Staedel and Fabien Darfeuille},
  booktitle={Silence},
  year={2011}
}
BACKGROUND MicroRNAs, post-transcriptional regulators of eukaryotic gene expression, are implicated in host defense against pathogens. Viruses and bacteria have evolved strategies that suppress microRNA functions, resulting in a sustainable infection. In this work we report that Helicobacter pylori, a human stomach-colonizing bacterium responsible for severe gastric inflammatory diseases and gastric cancers, downregulates an embryonic stem cell microRNA cluster in proliferating gastric… CONTINUE READING
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