Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

@article{Matsumoto2007HelicobacterPI,
  title={Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium},
  author={Yuko Matsumoto and Hiroyuki Marusawa and K Kinoshita and Yoko Endo and Tadayuki Kou and Toshiyuki Morisawa and Takeshi Azuma and Il-Mi Okazaki and T. Honjo and Tsutomu Chiba},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={470-476}
}
Infection with Helicobacter pylori (H. pylori) is a risk factor for the development of gastric cancer. Here we show that infection of gastric epithelial cells with 'cag' pathogenicity island (cagPAI)-positive H. pylori induced aberrant expression of activation-induced cytidine deaminase (AID), a member of the cytidine-deaminase family that acts as a DNA- and RNA-editing enzyme, via the IκB kinase–dependent nuclear factor-κB activation pathway. H. pylori–mediated upregulation of AID resulted in… CONTINUE READING

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