Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans.

@article{Peterson2010HelicobacterPI,
  title={Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans.},
  author={Anthony J Peterson and Trevelyan R. Menheniott and Louise O'Connor and Anna K. Walduck and James G Fox and Kazuyuki Kawakami and Toshinari Minamoto and E. K. Ong and Timothy C Wang and Louise M. Judd and Andrew S. Giraud},
  journal={Gastroenterology},
  year={2010},
  volume={139 6},
  pages={2005-17}
}
BACKGROUND & AIMS Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in the stomach. Tff1 deficiency results in gastric cancer, whereas Tff2 deficiency increases gastric inflammation. TFF2 expression is frequently lost in gastric neoplasms, but the nature of the silencing mechanism and associated impact on tumorigenesis have not been determined. METHODS We investigated the epigenetic silencing of TFF2 in gastric biopsy specimens from individuals with Helicobacter… CONTINUE READING

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