Helicobacter pylori infection and the pathogenesis of gastric cancer: a paradigm for host-bacterial interactions.

@article{McNamara2008HelicobacterPI,
  title={Helicobacter pylori infection and the pathogenesis of gastric cancer: a paradigm for host-bacterial interactions.},
  author={Deirdre McNamara and Emad-M El-Omar},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  year={2008},
  volume={40 7},
  pages={504-9}
}
Helicobacter pylori infection is the most important acquired risk factor for gastric cancer. The infection initiates a chronic inflammatory process that eventually alters the physiology of the gastric environment and leads to achlorohydria. Gastric atrophy may be part of this process but cancer can arise without this precursor. The net effect of decades of inflammation is the establishment of a milieu awash with pro-inflammatory cytokines and characterized by the activation of signalling… CONTINUE READING

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