Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner.

@article{Oliveira2006HelicobacterPI,
  title={Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner.},
  author={Maria Jos{\'e} Oliveira and Ana Catarina Costa and Angela Margarida Costa and L Magalli Pinto Henriques and Gianpaolo Suriano and John Christopher Atherton and Jos{\'e} Carlos Machado and F{\'a}tima Carneiro and Raquel Seruca and Marc Mareel and Ancy Leroy and Ceu Figueiredo},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 46},
  pages={34888-96}
}
Helicobacter pylori interacts with gastric epithelial cells, activating signaling pathways important for carcinogenesis. In this study we examined the role of H. pylori on cell invasion and the molecular mechanisms underlying this process. The relevance of H. pylori cag pathogenicity island-encoded type IV secretion system (T4SS), CagA, and VacA for cell invasion was also investigated. We found that H. pylori induces AGS cell invasion in collagen type I and in Matrigel invasion assays. H… CONTINUE READING