Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x.

@article{Marcos2008HelicobacterPI,
  title={Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis x.},
  author={Nuno T Marcos and Ana Elisa Mota Silveira Magalh{\~a}es and Bibiana Ferreira and Maria Jos{\'e} Oliveira and Ana Sofia Carvalho and Nuno Mendes and Tim J. Gilmartin and Steven Robert Head and Ceu Figueiredo and Leonor David and Filipe Santos-Silva and Celso A Reis},
  journal={The Journal of clinical investigation},
  year={2008},
  volume={118 6},
  pages={2325-36}
}
Chronic Helicobacter pylori infection is recognized as a cause of gastric cancer. H. pylori adhesion to gastric cells is mediated by bacterial adhesins such as sialic acid-binding adhesin (SabA), which binds the carbohydrate structure sialyl-Lewis x. Sialyl-Lewis x expression in the gastric epithelium is induced during persistent H. pylori infection, suggesting that H. pylori modulates host cell glycosylation patterns for enhanced adhesion. Here, we evaluate changes in the glycosylation-related… CONTINUE READING
42 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Similar Papers

Loading similar papers…