Helicobacter pylori-induced inhibition of vascular endothelial cell functions: a role for VacA-dependent nitric oxide reduction.

@article{Tobin2008HelicobacterPI,
  title={Helicobacter pylori-induced inhibition of vascular endothelial cell functions: a role for VacA-dependent nitric oxide reduction.},
  author={N P Tobin and Gary T. M. Henehan and Ronan P. Murphy and John Christopher Atherton and Anthony F Guinan and Steven W. Kerrigan and Dermot Cox and Paul A. Cahill and Philip M Cummins},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 4},
  pages={H1403-13}
}
Epidemiological and clinical studies provide compelling support for a causal relationship between Helicobacter pylori infection and endothelial dysfunction, leading to vascular diseases. However, clear biochemical evidence for this association is limited. In the present study, we have conducted a comprehensive investigation of endothelial injury in bovine aortic endothelial cells (BAECs) induced by H. pylori-conditioned medium (HPCM) prepared from H. pylori 60190 [vacuolating cytotoxin A (Vac… CONTINUE READING