Helicobacter pylori gamma-glutamyl transpeptidase is a pathogenic factor in the development of peptic ulcer disease.

@article{Gong2010HelicobacterPG,
  title={Helicobacter pylori gamma-glutamyl transpeptidase is a pathogenic factor in the development of peptic ulcer disease.},
  author={Min Gong and Samantha Shi Min Ling and Sook Yin Lui and Khay Guan Yeoh and Bow Ho},
  journal={Gastroenterology},
  year={2010},
  volume={139 2},
  pages={564-73}
}
BACKGROUND & AIMS gamma-Glutamyl transpeptidase (GGT) has been reported to be a virulence factor of Helicobacter pylori associated with bacterial colonization and cell apoptosis. But its mechanism of pathogenesis is not firmly established. This study aims to examine its role in H pylori-mediated infection. METHODS Various H pylori isogenic mutants were constructed by a polymerase chain reaction (PCR) approach. H pylori native GGT protein (HP-nGGT) was purified with ion-exchange and gel… CONTINUE READING

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