Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells.

@article{Giannakis2008HelicobacterPE,
  title={Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells.},
  author={Marios Giannakis and Swaine L Chen and Sherif M. Karam and Lars Engstrand and Jeffrey I. Gordon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 11},
  pages={4358-63}
}
We have characterized the adaptations of Helicobacter pylori to a rarely captured event in the evolution of its impact on host biology-the transition from chronic atrophic gastritis (ChAG) to gastric adenocarcinoma-and defined the impact of these adaptations on an intriguing but poorly characterized interaction between this bacterium and gastric epithelial stem cells. Bacterial isolates were obtained from a single human host colonized with a single dominant strain before and after his… CONTINUE READING

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