Helicobacter pylori encoding the pathogenicity island activates matrix metalloproteinase 1 in gastric epithelial cells via JNK and ERK.

@article{Krueger2006HelicobacterPE,
  title={Helicobacter pylori encoding the pathogenicity island activates matrix metalloproteinase 1 in gastric epithelial cells via JNK and ERK.},
  author={Sabine Krueger and T. F. W. Hundertmark and Thomas Kalinski and Ulrich Peitz and Thomas Wex and P Malfertheiner and Michael Naumann and Albert Roessner},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 5},
  pages={2868-75}
}
Helicobacter pylori colonizes the human gastric epithelium and induces an inflammatory response that is a trigger for gastric carcinogenesis. Matrix metalloproteinases (MMPs) have recently been shown to be up-regulated in gastric epithelial cells infected with H. pylori and might contribute to the pathogenesis of peptic ulcer. The aim of this study was to extend the knowledge about the effect of H. pylori infection on MMP-1 expression by gastric epithelial cells, the kinetics of induction, the… CONTINUE READING