Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host.

@article{Buti2011HelicobacterPC,
  title={Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host.},
  author={Ludovico Buti and Eric Spooner and Annemarthe G van der Veen and Rino Rappuoli and Antonello Covacci and Hidde L. Ploegh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 22},
  pages={9238-43}
}
Type I strains of Helicobacter pylori (Hp) possess a pathogenicity island, cag, that encodes the effector protein cytotoxin-associated gene A (CagA) and a type four secretion system. After translocation into the host cell, CagA affects cell shape, increases cell motility, abrogates junctional activity, and promotes an epithelial to mesenchymal transition-like phenotype. Transgenic expression of CagA enhances gastrointestinal and intestinal carcinomas as well as myeloid and B-cell lymphomas in… CONTINUE READING

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