Helicobacter pylori and molecular mechanisms of gastric carcinogenesis: targets for prevention and therapy.

Abstract

Gastric cancer is still a leading cause of cancer death worldwide. It is frequently diagnosed in an advanced stage and the overall prognosis is dismal. A major improvement will only be reached with a better understanding of the genetic changes underlying gastric cancer, which may provide us with effective prevention and treatment strategies. This review will highlight the present knowledge on the role of Helicobacter pylori in gastric carcinogenesis and the molecular pathogenesis of gastric cancer, as well as provide a brief overview of possible future targets for more specific and successful treatment options.

Cite this paper

@article{Juhsz2004HelicobacterPA, title={Helicobacter pylori and molecular mechanisms of gastric carcinogenesis: targets for prevention and therapy.}, author={M{\'a}rk Juh{\'a}sz and L{\'a}szl{\'o} Hersz{\'e}nyi and Zsolt Tulassay and P Malfertheiner and Matthias P. A. Ebert}, journal={Expert review of anticancer therapy}, year={2004}, volume={4 1}, pages={97-103} }