Helicobacter pylori and gastric acid: biological and therapeutic implications.

  title={Helicobacter pylori and gastric acid: biological and therapeutic implications.},
  author={Catherine C. McGowan and Timothy L Cover and Martin J. Blaser},
  volume={110 3},
Helicobacter pylori is highly adapted to its unusual ecological niche in the human stomach. Urease activity permits H. pylori survival at a pH of <4 in vitro and is required for the organism to colonize in animal models. However, urease does not play an important role in the survival of the organism in a pH range between 4 and 7. Other mechanisms of pH homeostasis remain poorly understood, but preliminary studies indicate that novel proteins are produced when H.pylori cells are shifted from pH… CONTINUE READING