Helicobacter pylori and atrophic gastritis: importance of the cagA status.

  title={Helicobacter pylori and atrophic gastritis: importance of the cagA status.},
  author={Ernst J Kuipers and Guillermo I Perez-Perez and Stefan G. M. Meuwissen and Martin J. Blaser},
  journal={Journal of the National Cancer Institute},
  volume={87 23},
BACKGROUND Infection with Helicobacter pylori is a major risk factor for the development of atrophic gastritis and gastric cancer. H. pylori strains can differ with respect to the presence of cagA (cytotoxin-associated gene A), a gene encoding a high-molecular-weight immunodominant antigen. H. pylori strains possessing cagA have been associated with enhanced induction of acute gastric inflammation. PURPOSE We investigated the relationship between cagA status and the development of atrophic… CONTINUE READING


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