Helicobacter pylori VacA subdomain required for intracellular toxin activity and 1 assembly of functional oligomeric complexes 2 3

Abstract

17 Helicobacter pylori VacA is a secreted pore-forming toxin that is comprised of two 18 domains, designated p33 and p55. The p55 domain has an important role in binding of VacA to 19 the cell surface. About 111 residues at the amino-terminus of p55 (residues 312-422) are 20 essential for the intracellular activity of VacA, which suggests that this region… (More)

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