Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521

@inproceedings{Nakano2016HelicobacterPV,
  title={Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521},
  author={Masayuki Nakano and Kinnosuke Yahiro and Eiki Yamasaki and Hisao Kurazono and Junko K. Akada and Yoshio Yamaoka and Takuro Niidome and Masanori Hatakeyama and Hidekazu Suzuki and Taro Yamamoto and Joel Moss and Hajime Isomoto and Toshiya Hirayama},
  booktitle={Disease models & mechanisms},
  year={2016}
}
Helicobacter pylori, a major cause of gastroduodenal diseases, produces vacuolating cytotoxin (VacA) and cytotoxin-associated gene A (CagA), which seem to be involved in virulence. VacA exhibits pleiotropic actions in gastroduodenal disorders via its specific receptors. Recently, we found that VacA induced the phosphorylation of cellular Src kinase (Src) at Tyr418 in AZ-521 cells. Silencing of receptor protein tyrosine phosphatase (RPTP)α, a VacA receptor, reduced VacA-induced Src… CONTINUE READING