Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation.

@article{Mahdavi2002HelicobacterPS,
  title={Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation.},
  author={Jafar Mahdavi and Berit Sond{\'e}n and Marina Hurtig and Farzad O. Olfat and Lina Forsberg and Niamh Roche and Jonas Angstrom and Thomas B. Larsson and Susann Teneberg and Karl-Anders Karlsson and Siiri Altraja and Torkel Mikael Wadstroem and Dangeruta Kersulyte and Douglas E. Berg and Andr{\'e} DuBois and Christoffer Petersson and Karl-Eric Magnusson and Thomas Norberg and Frank R. Lindh and Bertil B Lundskog and Anna Arnqvist and Lennart Hammarstr{\"o}m and Thomas Bor{\'e}n},
  journal={Nature Reviews Molecular Cell Biology},
  year={2002},
  volume={3},
  pages={635-635}
}
Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified… CONTINUE READING
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