Helicobacter pylori Infection Causes Characteristic DNA Damage Patterns in Human Cells.

  title={Helicobacter pylori Infection Causes Characteristic DNA Damage Patterns in Human Cells.},
  author={Max Koeppel and Fernando Garc{\'i}a-Alcalde and Frithjof Glowinski and Philipp Schlaermann and Thomas F. Meyer},
  journal={Cell reports},
  volume={11 11},
Infection with the human pathogen Helicobacter pylori (H. pylori) is a major risk factor for gastric cancer. Since the bacterium exerts multiple genotoxic effects, we examined the circumstances of DNA damage accumulation and identified regions within the host genome with high susceptibility to H. pylori-induced damage. Infection impaired several DNA repair factors, the extent of which depends on a functional cagPAI. This leads to accumulation of a unique DNA damage pattern, preferentially in… CONTINUE READING
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