Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis

  title={Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis},
  author={M. Hatakeyama and Hideaki Higashi},
  journal={Cancer Science},
  • M. Hatakeyama, Hideaki Higashi
  • Published 2005
  • Biology, Medicine
  • Cancer Science
  • Infection with cagA‐positive Helicobacter pylori is associated with the development of gastric adenocarcinoma. The cagA gene product CagA is injected directly from the bacterium into the bacterium‐attached gastric epithelial cells via the type‐IV secretion system. Upon membrane localization and subsequent tyrosine phosphorylation by Src family kinases, CagA functions as a scaffolding adaptor and interacts with a number of host proteins that regulate cell growth, cell motility and cell polarity… CONTINUE READING
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