Helicobacter pylori AddAB helicase-nuclease and RecA promote recombination-related DNA repair and survival during stomach colonization.

@article{Amundsen2008HelicobacterPA,
  title={Helicobacter pylori AddAB helicase-nuclease and RecA promote recombination-related DNA repair and survival during stomach colonization.},
  author={Susan K. Amundsen and Jutta B Fero and Lori M. Hansen and Gareth A Cromie and Jay V. Solnick and Gerald R Smith and Nina R Salama},
  journal={Molecular microbiology},
  year={2008},
  volume={69 4},
  pages={994-1007}
}
Helicobacter pylori colonization of the human stomach is characterized by profound disease-causing inflammation. Bacterial proteins that detoxify reactive oxygen species or recognize damaged DNA adducts promote infection, suggesting that H. pylori requires DNA damage repair for successful in vivo colonization. The molecular mechanisms of repair remain unknown. We identified homologues of the AddAB class of helicase-nuclease enzymes, related to the Escherichia coli RecBCD enzyme, which, with… CONTINUE READING
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