Helicobacter infection and gastric neoplasia

  title={Helicobacter infection and gastric neoplasia},
  author={R. Peek and J. Crabtree},
  journal={The Journal of Pathology},
  • R. Peek, J. Crabtree
  • Published 2006
  • Medicine, Biology
  • The Journal of Pathology
  • Chronic gastritis induced by Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the distal stomach, yet only a minority of people who harbour this organism ever develop cancer. H. pylori isolates possess substantial genotypic diversity, which engenders differential host inflammatory responses that influence clinical outcome. H. pylori strains that possess the cag pathogenicity island and secrete a functional cytotoxin induce more severe gastric injury and further… CONTINUE READING
    443 Citations
    Review: Prevention of gastric cancer: When is treatment of Helicobacter pylori warranted?
    • R. Peek
    • Medicine
    • Therapeutic advances in gastroenterology
    • 2008
    • 3
    Helicobacter pylori and gastric cancer
    • 20
    From inflammation to gastric cancer: Role of Helicobacter pylori
    • 42
    • PDF
    Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk
    • 809
    • PDF
    Role of innate immunity in Helicobacter pylori-induced gastric malignancy.
    • 184
    • PDF
    Helicobacter pylori in gastric carcinogenesis.
    • 59


    Helicobacter pylori-induced epithelial cell signalling in gastric carcinogenesis.
    • 131
    • PDF
    Host mechanisms: are they the key to the various clinical outcomes of Helicobacter pylori infection?
    • J. Calam
    • Medicine
    • Italian journal of gastroenterology and hepatology
    • 1997
    • 12
    Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    • 2,280
    • PDF
    Activation of β-catenin by carcinogenic Helicobacter pylori
    • 380
    • PDF
    Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses.
    • 316
    • PDF
    Helicobacter pylori and gastrointestinal tract adenocarcinomas
    • 1,583
    • PDF
    Chronic Helicobacter pylori infections induce gastric mutations in mice.
    • 156
    Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific.
    • 192
    • PDF
    Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia.
    • 172