Helicobacter infection and gastric neoplasia

@article{Peek2006HelicobacterIA,
  title={Helicobacter infection and gastric neoplasia},
  author={Richard M Peek and Jean E. Crabtree},
  journal={The Journal of Pathology},
  year={2006},
  volume={208}
}
Chronic gastritis induced by Helicobacter pylori is the strongest known risk factor for adenocarcinoma of the distal stomach, yet only a minority of people who harbour this organism ever develop cancer. H. pylori isolates possess substantial genotypic diversity, which engenders differential host inflammatory responses that influence clinical outcome. H. pylori strains that possess the cag pathogenicity island and secrete a functional cytotoxin induce more severe gastric injury and further… Expand
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Much interest has been shown in the relationship between Helicobacter pylori infection and gastric carcinogenesis. It is becoming clearer that H. pylori strains carrying a functional cagExpand
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