Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin.

@article{Rieder2005HelicobacterinducedIM,
  title={Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin.},
  author={Gabriele Rieder and Arthur J Tessier and Xiaotan T. Qiao and Blair Madison and Deborah L Gumucio and Juanita L Merchant},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 6},
  pages={4906-12}
}
Chronic Helicobacter pylori infection results in serious sequelae, including atrophy, intestinal metaplasia, and gastric cancer. Intestinal metaplasia in the stomach is defined by the presence of intestine-like cells expressing enterocyte-specific markers, such as villin. In this study, we demonstrate that villin is expressed in intestine-like cells that develop after chronic infection with H. pylori in both human stomach and in a mouse model. Transfection studies were used to identify specific… CONTINUE READING

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