Helical peptide arrays for lead identification and interaction site mapping.

@article{Langedijk2011HelicalPA,
  title={Helical peptide arrays for lead identification and interaction site mapping.},
  author={Johannes P Langedijk and Maria J. Zekveld and Mariska Ruiter and Davide Corti and Jaap Willem Back},
  journal={Analytical biochemistry},
  year={2011},
  volume={417 1},
  pages={149-55}
}
Libraries composed of linear and cyclic peptides cannot fully represent the higher order structures of most antigenic sites. To map the binding site of ligands or antibodies, a larger part of the three-dimensional space should be sampled. Because parallel synthesis of large arrays of peptides on hydrogels is restricted to relatively small peptides, a simple and robust homodimeric helical system was chosen for antigen presentation. First, it was established in an heterodimeric system that the 26… CONTINUE READING