Helical hairpin structure of a potent antimicrobial peptide MSI-594 in lipopolysaccharide micelles by NMR spectroscopy.

@article{Bhunia2009HelicalHS,
  title={Helical hairpin structure of a potent antimicrobial peptide MSI-594 in lipopolysaccharide micelles by NMR spectroscopy.},
  author={Anirban Bhunia and Ayyalusamy Ramamoorthy and Surajit Bhattacharjya},
  journal={Chemistry},
  year={2009},
  volume={15 9},
  pages={
          2036-40
        }
}
Essential understanding: Elucidation of structural requirements and interactions of antimicrobial peptides with lipopolysaccharide (LPS) are essential to understand the mechanism of action of antimicrobial peptides. The highly active antimicrobial peptide MSI-594 (see figure for electrostatic potential surface) acquires a novel helical hairpin structure in complex with LPS. The structure and interactions of MSI-594 with LPS presented here provide important insights into the mechanism of outer… CONTINUE READING
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