Helical chiral pyridine N-oxides: a new family of asymmetric catalysts.

@article{Chen2009HelicalCP,
  title={Helical chiral pyridine N-oxides: a new family of asymmetric catalysts.},
  author={Jinshui Chen and Norito Takenaka},
  journal={Chemistry},
  year={2009},
  volume={15 30},
  pages={7268-76}
}
Optically active chiral alkyl chlorides are valuable compounds because of their bioactivity and versatile synthetic utility. Accordingly, the ring opening of epoxides with a chloride nucleophile stands as an important goal in asymmetric catalysis. We describe herein recent advances in the design and development of chiral pyridine N-oxide catalysts for the enantioselective synthesis of chlorohydrins.